The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. All of the Week 16 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 16 NFL picks now. Philadelphia has won 13 of its 14 games this season, including a 26-17 win over the Cowboys in Week 6, but will be without quarterback Jalen Hurts (shoulder), setting up plenty of questions as you set your NFL bets. They are 4.5-point favorites against Philadelphia in the latest Week 16 NFL odds at Caesars Sportsbook, one of the larger NFL spreads of the week. Dallas will try to bounce back from an overtime loss to Jacksonville when it faces NFC East rival Philadelphia on Saturday.

The playoff race is heating up, with the Week 16 NFL schedule featuring many important matchups.

Nfl vegas odds week 16